Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Apr 21;13(15):2247-9.
doi: 10.3748/wjg.v13.i15.2247.

Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: a case report

Takeo Bamba  1 , Shinichi Kosugi, Tatsuo Kanda, Toshihiro Tsubono, Yasuo Sakai, Nobuyuki Musha, Noriko Ishihara, Katsuyoshi Hatakeyama
Affiliations
Review

Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: a case report

Takeo Bamba et al. World J Gastroenterol. .

Abstract

We report a case of multiple duodenal, pancreatic, and gastric carcinoids. A 67-year old woman was admitted to our hospital for treatment of a duodenal carcinoid. Laboratory tests revealed that the patient was associated with macrocytic anemia and hypergastrinemia, and type A gastritis was shown by gastrofiberscopy. During surgery, another tumor was incidentally found in the head of the pancreas. The tumors in the duodenum and pancreas were completely excised by pancreatoduodenectomy and immunohistologically diagnosed as gastrin-and serotonin-producing carcinoids, respectively. Pathological examination revealed that in addition to the grossly found carcinoids, there were subclinical carcinoids, one of which was an endocrine cell micronest, located in the stomach and duodenum. The tumors in the duodenum, pancreas, and stomach showed different characteristics from one another morphologically and immunochemically. Although no definitive evidence has been obtained, some sort of genetic anomaly may have been involved in this case, and hypergastrinemia due to duodenal gastrinoma may induce multiple gastric carcinoids.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histological examination of each carcinoid in three organs. A: Duodenal carcinoid showing anastomotic ribbon-like formation in the interstitium with predominant blood vessels and only a small amount of connective tissue (HE, × 10); B: A palisade-like carcinoid in the pancreas, and a moderate amount of fibrous connective tissue observed in the interstitium (HE, × 20); C: Vesicular carcinoids in the stomach (arrow) (HE, × 10).
Figure 2
Figure 2
Imunohistochemical staining of carcinoids in the duodenum and pancreas (× 20). A: Gatrin immunostaining showing a quite positive carcinoid in the duodenum; B: Serotonin immunostaining showing a strongly positive carcinoid in the pancreas.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Soga J. Carcinoids and their variant endocrinomas. An analysis of 11842 reported cases. J Exp Clin Cancer Res. 2003;22:517–530. - PubMed
    1. Kinouchi M, Shiiba K, Ishii S, Mizoi T, Oyama J, Matsuno S, Sasaki I. A case of multiple gastric carcinoid associated with hypergastrinemia. Jpn J Gastroenterol. 2004;37:1616–1621.
    1. Satake S, Ishado Y, Nakai R, Mukaeyama Y, Maeda S. Two cases of gastric carcinoid tumor associated with type A gastritis treated by distal gastrectomy. Jpn J Gastroenterol. 2003;36:1173–1177.
    1. Itsuno M, Watanabe H, Iwafuchi M, Ito S, Yanaihara N, Sato K, Kikuchi M, Akiyama N. Multiple carcinoids and endocrine cell micronests in type A gastritis. Their morphology, histogenesis, and natural history. Cancer. 1989;63:881–890. - PubMed
    1. Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology. 1993;104:994–1006. - PubMed

MeSH terms