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. 1991 Dec;49(6):1372-7.

Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12

D F Callen  1 , E Baker, S Lane, J Nancarrow, A Thompson, S A Whitmore, D H MacLennan, R Berger, D Cherif, I Järvelä, et al.
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Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12

D F Callen et al. Am J Hum Genet. 1991 Dec.

Abstract

The gene for Batten disease (CLN3) has been mapped to human chromosome 16 by demonstration of linkage to the haptoglobin locus, and its localization has been further refined using a panel of DNA markers. The aim of this work was to refine the genetic and physical mapping of this disease locus. Genetic linkage analysis was carried out in a larger group of families by using markers for five linked loci. Multipoint analysis indicated a most likely location for CLN3 in the interval between D16S67 and D16S148 (Z = 12.5). Physical mapping of linked markers was carried out using somatic cell hybrid analysis and in situ hybridization. A mouse/human hybrid cell panel containing various segments of chromosome 16 has been constructed. The relative order and physical location of breakpoints in the proximal portion of 16p were determined. Physical mapping in this panel of the markers for the loci flanking CLN3 positioned them to the bands 16p12.1----16p12.3. Fluorescent in situ hybridization of metaphase chromosomes by using these markers positioned them to the region 16p11.2-16p12.1. These results localize CLN3 to an interval of about 2 cM in the region 16p12.

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References

    1. Genomics. 1990 Oct;8(2):387-90 - PubMed
    1. Am J Hum Genet. 1988 Feb;42(2):373-9 - PubMed
    1. Cancer Genet Cytogenet. 1988 Sep;34(2):177-87 - PubMed
    1. Genomics. 1988 Feb;2(2):144-53 - PubMed
    1. Clin Genet. 1989 Oct;36(4):217-8 - PubMed

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