Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jun;19(3):317-20.
doi: 10.1016/j.ceb.2007.04.004. Epub 2007 Apr 27.

Long-range DNA contacts: romance in the nucleus?

Wouter de Laat  1
Affiliations
Review

Long-range DNA contacts: romance in the nucleus?

Wouter de Laat. Curr Opin Cell Biol. 2007 Jun.

Abstract

Recent studies show that genes far apart on the same chromosome or even on different chromosomes can come together in the nuclear space. It has been hypothesized that functionally related genes 'kiss' at transcription factories to coordinate their expression. Novel high-throughput methods, such as 4C technology, that study DNA interactions in an unbiased manner should uncover the generality of this romantic concept of nuclear architecture.

PubMed Disclaimer

Publication types

LinkOut - more resources