Review
doi: 10.1016/j.drudis.2007.03.010.
Epub 2007 Apr 6.
Harnessing bioinformatics to discover new vaccines
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- PMID: 17467575
- DOI: 10.1016/j.drudis.2007.03.010
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Review
Harnessing bioinformatics to discover new vaccines
Drug Discov Today.
2007 May.
Abstract
Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
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