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. 2007 May 15;581(10):2000-8.
doi: 10.1016/j.febslet.2007.04.022. Epub 2007 Apr 20.

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor

Kyoung Ah Kang  1 , Kyoung Hwa Lee, Jae Woo Park, Nam Ho Lee, Hye Kyung Na, Young Joon Surh, Ho Jin You, Myung Hee Chung, Jin Won Hyun
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Free article

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor

Kyoung Ah Kang et al. FEBS Lett. .
Free article

Abstract

Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heme oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-1 activity. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol-A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol-A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol-A induced activation of Nrf2, finally decreased HO-1 protein level. Taken together, these data suggest that triphlorethol-A augments cellular antioxidant defense capacity through induction of HO-1 via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress.

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