Review
doi: 10.1016/j.biocel.2007.01.028.
Epub 2007 Mar 21.
Acute promyelocytic leukemia: new issues on pathogenesis and treatment response
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- PMID: 17468032
- DOI: 10.1016/j.biocel.2007.01.028
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Review
Acute promyelocytic leukemia: new issues on pathogenesis and treatment response
Int J Biochem Cell Biol.
2007.
Abstract
Pathogenesis of acute promyelocytic leukemia appears to be one of the best understood among human malignancies. The ability of retinoic acid (RA) and arsenic trioxide to directly target the oncogenic promyelocytic leukemia-retinoic receptor A (PML-RARA) fusion protein also made this disease the first model for oncogene-targeted therapies. A set of recent data has significantly increased the complexity of our view of acute promyelocytic leukemia pathogenesis, as well as of therapeutic response. This review summarizes and discusses these findings, which yield novels questions and models.
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