Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jun;10(6):679-81.
doi: 10.1038/nn1899. Epub 2007 Apr 29.

Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition

Alessandro Sale  1 , José Fernando Maya Vetencourt, Paolo Medini, Maria Cristina Cenni, Laura Baroncelli, Roberto De Pasquale, Lamberto Maffei
Affiliations

Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition

Alessandro Sale et al. Nat Neurosci. 2007 Jun.

Abstract

Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources