Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007;37(5):383-8.
doi: 10.1007/s00595-006-3410-7. Epub 2007 Apr 30.

Randomized clinical trial comparing intravenous antimicrobial prophylaxis alone with oral and intravenous antimicrobial prophylaxis for the prevention of a surgical site infection in colorectal cancer surgery

Minako Kobayashi  1 , Yasuhiko Mohri, Hitoshi Tonouchi, Chikao Miki, Keiji Nakai, Masato Kusunoki; Mie Surgical Infection Research Group
Affiliations
Randomized Controlled Trial

Randomized clinical trial comparing intravenous antimicrobial prophylaxis alone with oral and intravenous antimicrobial prophylaxis for the prevention of a surgical site infection in colorectal cancer surgery

Minako Kobayashi et al. Surg Today. 2007.

Abstract

Purpose: The use of preoperative oral antibiotics during preparation for elective colorectal surgery remains controversial. This was a prospective randomized clinical trial to compare the efficacy of intravenous antimicrobial prophylaxis alone with combined oral and intravenous antimicrobial prophylaxis for surgical site infection (SSI) in patients undergoing elective colorectal surgery.

Methods: Five hundred patients were enrolled in this study. Of these, 491 were randomly assigned to receive either intravenous antimicrobial prophylaxis or combined oral and intravenous antimicrobial prophylaxis. The primary outcome was the incidence of SSI within 6 weeks of elective colorectal surgery.

Results: The incidence of SSI was similar in the two treatment groups: intravenous alone, 10.7%; and oral and intravenous, 7.0% (difference 3.7%; 95% confidence interval -4.8% to 5.6%). No critical adverse events were reported.

Conclusion: The addition of oral antibiotics to intravenous antimicrobial prophylaxis showed no advantage in the prevention of SSI.

PubMed Disclaimer

References

    1. J Chemother. 1999 Dec;11(6):551-5 - PubMed
    1. Br Med J (Clin Res Ed). 1982 Sep 25;285(6345):871-3 - PubMed
    1. Am J Surg. 1979 Jan;137(1):68-74 - PubMed
    1. Can J Surg. 2002 Jun;45(3):173-80 - PubMed
    1. World J Surg. 1982 Mar;6(2):175-81 - PubMed

Publication types

LinkOut - more resources