Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jul;33(7):1199-1203.
doi: 10.1007/s00134-007-0649-4. Epub 2007 Apr 28.

Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome

Michael Adamzik  1   2 , Ulrich H Frey  3   4 , Kathrin Rieman  3 , Stephan Sixt  4 , Martin Beiderlinden  4 , Winfried Siffert  3 , Jürgen Peters  4
Affiliations

Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome

Michael Adamzik et al. Intensive Care Med. 2007 Jul.

Abstract

Objective: This study investigated whether the insertion/deletion polymorphism in the promoter of NFKB1 is associated with severity and/or mortality in ARDS.

Design and setting: Prospective study in a mixed anesthesiological ICU of the University Hospital Essen.

Patients and participants: 103 adult patients with ARDS (white Germans).

Measurements and results: Patients with ARDS were genotyped for the insertion/deletion polymorphism in the promoter of NFKB1 (-94ins/delATTG). In ARDS patients genotypes differed significantly between those with severe ARDS [Lung Injury Score (LIS)>or=3; 23 homozygote deletion (DD), heterozygote (ID) 31, and homozygote insertion wildtype (II) 23], and those with LIS below 3 (1 DD, 9 ID, 16 II). Likewise, the frequency of the D allele was significantly less in patients with higher LIS (50% D) than lower LIS (21% D). Using these values produces a significantly higher OR of 16.0 (95% CI 1.96-130.9) for DD than for II, while the OR for ID vs. II was 2.4 (95% CI 0.9-6.4). Genotypes of the NFKB1 promoter polymorphism were associated neither with 30-day survival nor with duration of ICU stay.

Conclusions: The insertion/deletion polymorphism in the promoter of NFKB1 influences the severity but not the mortality of ARDS.

PubMed Disclaimer

References

    1. Am J Respir Crit Care Med. 2003 Apr 1;167(7):1027-35 - PubMed
    1. Immunobiology. 1997 Dec;198(1-3):73-80 - PubMed
    1. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24 - PubMed
    1. Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):602-11 - PubMed
    1. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1818-24 - PubMed

Substances

LinkOut - more resources