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. 2007 Mar;4(1):44-8.
doi: 10.3132/dvdr.2007.005.

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus

Justin M S Lee  1 , Cheerag Shirodaria, Clare E Jackson, Matthew D Robson, Charalambos Antoniades, Jane M Francis, Frank Wiesmann, Keith M Channon, Stefan Neubauer, Robin P Choudhury
Affiliations

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus

Justin M S Lee et al. Diab Vasc Dis Res. 2007 Mar.

Abstract

Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy.

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Figures

Figure 1
Figure 1
Aortic distensibility. (a): sagittal pilot image of the aorta is used to select two transverse planes (indicated by white lines) for ECG-gated steady state free precession (SSFP) cine acquisitions. Still images of the ascending (AA), proximal descending (PDA) and distal descending aorta (DDA) are shown during diastole and systole. (b): distensibility
Figure 2
Figure 2
Brachial artery reactivity. (a): transverse image of arm; higher magnification shows brachial artery (BA) at baseline and after hyperaemia due to cuff release. (b): brachial artery responses to flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN).
Figure 3
Figure 3
Aortic wall area. (a): high-resolution transverse image of aortic plaque – inner and outer wall boundaries are contoured to derive wall and lumen areas. (b): Aortic wall area vs. distensibility. Blue squares and solid regression line, control subjects (R = −0.61, p<0.01); yellow triangles and dashed regression line, subjects with diabetes (R=−0.18; p=ns)
See this image and copyright information in PMC

References

    1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–7. - PubMed
    1. Topol EJ, Nissen SE. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation. 1995;92:2333–42. - PubMed
    1. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–15. - PubMed
    1. Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1996;27:567–74. - PubMed
    1. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601–10. - PMC - PubMed

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