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Clinical Trial
. 1991 Dec;18(15):2581-8.

[A comparative clinical study of adjuvant chemotherapy of tumors in the head and neck areas by means of HCFU]

[Article in Japanese]
K Yoshino  1 , T Sato, Y Nakai, M Tanabe, T Matsunaga, T Kozuka, S Sakai, M Miyaguchi, T Nishimura, H Matsuoka, et al.
Affiliations
  • PMID: 1746970
Clinical Trial

[A comparative clinical study of adjuvant chemotherapy of tumors in the head and neck areas by means of HCFU]

[Article in Japanese]
K Yoshino et al. Gan To Kagaku Ryoho. 1991 Dec.

Abstract

In order to evaluate the efficacy of HCFU as an adjuvant chemotherapy agent for squamous cell carcinoma of the head and neck areas, a randomized comparative study was performed with cooperative facilities. 191 patients who had undergone radical therapy were randomly assigned to the following two groups: Group A was the control group, which underwent radical therapy only, and Group B was a group which received long-term HCFU administration (300-600 mg/day x 12 weeks or more). In the comparison of non-recurrence rate in both groups, Group B had better results among patients who were at the advanced clinical stages such as N1 through N3, Stage II (p = 0.0583) and Stage III (p = 0.0970). The adverse reactions to HCFU included pollakiuria, feverishness, and digestive symptoms, but these were mild and the recovery was possible.

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