Genome integrity: a HAT needs a chaperone
- PMID: 17470345
- DOI: 10.1016/j.cub.2007.03.011
Genome integrity: a HAT needs a chaperone
Abstract
Histone acetylation helps to maintain integrity of the yeast replisome in response to genotoxic agents. Four groups have now identified protein Rtt109p as the catalytic subunit of a novel histone H3 acetylase complex that harbors a histone chaperone subunit essential for significant activity.
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