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Review
. 2007 May 1;17(9):R326-8.
doi: 10.1016/j.cub.2007.03.013.

Chromosome congression: the kinesin-8-step path to alignment

Jason Stumpff  1 , Linda Wordeman
Affiliations
Review

Chromosome congression: the kinesin-8-step path to alignment

Jason Stumpff et al. Curr Biol. .

Abstract

During mitosis, chromosomes must become aligned at the equator of the mitotic spindle before segregation. Recent work suggests that a kinesin-8 motor uses a unique combination of activities to regulate this process.

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Figures

Figure 1
Figure 1
Effects of kinesin-8 depletion in live cells. (A) Depletion of Kif18A results in longer spindles and chromosomes that do not line up at the metaphase plate. (B) Loss of yeast Kip3 results in microtubules that spend comparatively more time growing than attenuated relative to wild-type cells. Data modified from Gupta et al., 2006 [11].
See this image and copyright information in PMC

Comment on

References

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