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. 2007 Dec;78(12):1310-3.
doi: 10.1136/jnnp.2006.111609. Epub 2007 Apr 30.

Hyperacusis in patients with complex regional pain syndrome related dystonia

M J M de Klaver  1 , M A van Rijn, J Marinus, W Soede, J A P M de Laat, J J van Hilten
Affiliations

Hyperacusis in patients with complex regional pain syndrome related dystonia

M J M de Klaver et al. J Neurol Neurosurg Psychiatry. 2007 Dec.

Abstract

Introduction: In complex regional pain syndrome type 1 (CRPS-1), patients may have manifestations of central involvement, including allodynia, hyperalgesia or dystonia. We noted that more severely affected patients may experience hyperacusis, which may also reflect central involvement. The aim of this study was to evaluate the occurrence and characteristics of hyperacusis in patients with CRPS related dystonia.

Methods: The presence of hyperacusis, speech reception thresholds (SRT), pure-tone thresholds (PTT) and uncomfortable loudness (UCL) was evaluated in 40 patients with CRPS related dystonia.

Results: PTT and SRT were normal for all patients. 15 patients (38%) reported hyperacusis and this was associated with allodynia/hyperalgesia and with more affected extremities. UCLs of patients with hyperacusis were significantly lower than UCLs of patients without hyperacusis.

Conclusion: Hyperacusis is common among severely affected patients with CRPS related dystonia and may indicate that the disease spreads beyond those circuits related to sensory-motor processing of extremities.

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Conflict of interest statement

Competing interests: None.

References

    1. Allen G, Galer B S, Schwartz L. Epidemiology of complex regional pain syndrome: a retrospective chart review of 134 patients. Pain 199980539–544. - PubMed
    1. Veldman P H, Reynen H M, Arntz I E.et al Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 19933421012–1016. - PubMed
    1. van Hilten J J, Blumberg H, Factor I V. Movement disorders and dystrophy—pathofiology and measurements. In: Wilson PR, Stanton‐Hicks MS, Harden RN, eds. CRPS: current diagnosis and therapie. Seattle: IASP Press, 2005119–137.
    1. van Hilten J J, van de Beek W J, Hoff J I.et al Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. N Engl J Med 2000343625–630. - PubMed
    1. Schaaf H, Klofat B, Hesse G. Hyperacusis, phonophobia, and recruitment. Abnormal deviations of hearing associated with hypersensitivity to sound. HNO 2003511005–1011. - PubMed

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