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. 2007 Aug;51(8):2855-60.
doi: 10.1128/AAC.01614-06. Epub 2007 Apr 30.

Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland

Marie-Frédérique Lartigue  1 , Catherine Zinsius, Aline Wenger, Jacques Bille, Laurent Poirel, Patrice Nordmann
Affiliations

Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland

Marie-Frédérique Lartigue et al. Antimicrob Agents Chemother. 2007 Aug.

Abstract

The epidemiology of clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) was investigated among infection-associated enterobacterial isolates at the University Hospital in Lausanne, Switzerland, from January 2004 to June 2005. Out of 57 nonrepetitive ESBL producers (prevalence rate of 0.7%), 45 produced CTX-M-like ESBLs. CTX-M enzymes were mostly from clonally nonrelated Escherichia coli isolates, from urinary infections and community-acquired infections. Pediatric patients (20 out of 57) accounted for a large number of CTX-M producers. CTX-M-15 was the most frequent CTX-M-type enzyme. The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland.

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Figures

FIG. 1.
FIG. 1.
Surrounding DNA sequences for the blaCTX-M genes for the 42 isolates. Row 1, E. coli 13 and 18; row 2, E. coli 7, 9, 11, 14, 15, 16, 17, 20, 22, 23, 26, 28, 29, 32, 33, 34, 35, 36, and 37; K. oxytoca 38; K. pneumoniae 39, 44, 46, 47, 48, 49, 50, 51, 52, 53, 54, and 55; P. mirabilis 56 and 57; row 3, E. coli 8, 10, 12, 14, 21, and 30 and P. mirabilis 57. IRR and IRL, inverted repeat (right) and inverted repeat (left), respectively.
See this image and copyright information in PMC

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