[Uremic toxins and bone metabolism]

Abstract

Patients with end-stage renal disease develop various kinds of abnormalities in bone and mineral metabolism. However, all patients share a common factor, the presence of uremic condition. Uremic toxins accumulate in the patient's plasma which under normal conditions is excreted by healthy kidneys. It remains unclear how each of these compounds affects bone metabolism. Recently, it has been elucidated that indoxyl sulfate, which is one of uremic toxins, impairs osteoblst function and induces abnormalities of bone turnover.