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Comment
. 2007 Jul-Aug;3(4):405-7.
doi: 10.4161/auto.4281. Epub 2007 Jul 13.

AMPK mediates autophagy during myocardial ischemia in vivo

Hiromitsu Takagi  1 , Yutaka Matsui, Shinichi Hirotani, Hideyuki Sakoda, Tomoichiro Asano, Junichi Sadoshima
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Comment

AMPK mediates autophagy during myocardial ischemia in vivo

Hiromitsu Takagi et al. Autophagy. 2007 Jul-Aug.

Abstract

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

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