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Review
. 2007 Jul;151(6):725-36.
doi: 10.1038/sj.bjp.0707263. Epub 2007 Apr 30.

Chemokines and their receptors as potential targets for the treatment of asthma

C Palmqvist  1 , A J Wardlaw, P Bradding
Affiliations
Review

Chemokines and their receptors as potential targets for the treatment of asthma

C Palmqvist et al. Br J Pharmacol. 2007 Jul.

Abstract

Asthma is a chronic and sometimes fatal disease, which affects people of all ages throughout the world. Important hallmarks of asthma are airway inflammation and remodelling, with associated bronchial hyperresponsiveness and variable airflow obstruction. These features are orchestrated by cells of both the innate (eosinophils, neutrophils and mast cells) and the adaptive (T(H)2 T cells) immune system, in concert with structural airway cells. Chemokines are important for the recruitment of both immune and structural cells to the lung, and also for their microlocalisation within the lung tissue. Specific blockade of the responses elicited by chemokines and chemokine receptors responsible for the pathological migration of airway cells could therefore be of great therapeutic interest for the treatment of asthma.

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Figures

Figure 1
Figure 1
Bronchial biopsy specimen from a patient with asthma showing mast cell infiltration of airway smooth muscle.
Figure 2
Figure 2
Chemokines and chemokine receptors with potential as therapeutic targets for the treatment of asthma.
See this image and copyright information in PMC

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