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Review
. 2007 Oct 18;256(1):1-24.
doi: 10.1016/j.canlet.2007.03.016. Epub 2007 May 1.

Pathways to tamoxifen resistance

Rebecca B Riggins  1 , Randy S Schrecengost, Michael S Guerrero, Amy H Bouton
Affiliations
Review

Pathways to tamoxifen resistance

Rebecca B Riggins et al. Cancer Lett. .

Abstract

Therapies that target the synthesis of estrogen or the function of estrogen receptor(s) have been developed to treat breast cancer. While these approaches have proven to be beneficial to a large number of patients, both de novo and acquired resistance to these drugs is a significant problem. Recent advances in our understanding of the molecular mechanisms that contribute to resistance have provided a means to begin to predict patient responses to these drugs and develop rational approaches for combining therapeutic agents to circumvent or desensitize the resistant phenotype. Here, we review common mechanisms of antiestrogen resistance and discuss the implications for prediction of response and design of effective combinatorial treatments.

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Figures

Figure 1
Figure 1
Molecular mechanisms of tamoxifen resistance. Model depicting molecules implicated in antiestrogen resistance and discussed in this review.
Figure 2
Figure 2
ERα phosphorylation. Domain structure of ERα showing phosphorylation sites and the kinases that mediate these phosphorylations.
See this image and copyright information in PMC

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