Age effects on monoamine turnover of the rat substantia nigra
- PMID: 1747745
- DOI: 10.1016/0006-8993(91)90122-c
Age effects on monoamine turnover of the rat substantia nigra
Abstract
Measurement of turnover of dopamine (DA), noradrenaline (NA) and serotonin (5-hydroxytryptamine (5-HT), and their metabolites has been performed in 6- and 24-month-old rats. Dopamine synthesis in 24-month-old rats did not show any change with respect to 6-month-old rats. However, our results seem to indicate decreased DA release in 24-month-old rats. This hypothesis could be supported by the changes found in the 3-methoxytyramine (3-MT) accumulation rate after monoamine oxidase inhibition with pargyline. The turnover of NA and its main metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG) decreased in 24-month-old rats compared with 6-month-old rats. Serotonin synthesis did not change in 24-month-old rats with respect to 6-month-old rats. However, the metabolism of 5-HT quantified as turnover of 5-hydroxy-3-indoleacetic acid (5-HIAA) increased in 24-month-old rats with respect to 6-month-old rats. The monoamine oxidase B:monoamine oxidase-A ratio increased in 24-month-old rats. The significance of these changes is discussed.
Similar articles
-
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.Mech Ageing Dev. 1993 Dec 15;72(2):105-18. doi: 10.1016/0047-6374(93)90093-7. Mech Ageing Dev. 1993. PMID: 7512183
-
Effects of acute administration of SCH 23390 on dopamine and serotonin turnover in major dopaminergic areas and mesencephalic raphe nuclei--comparison with ritanserin.Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(6):861-72. doi: 10.1016/0278-5846(91)90014-r. Prog Neuropsychopharmacol Biol Psychiatry. 1991. PMID: 1722342
-
The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra.Naunyn Schmiedebergs Arch Pharmacol. 1991 Jul;344(1):16-28. doi: 10.1007/BF00167378. Naunyn Schmiedebergs Arch Pharmacol. 1991. PMID: 1663587
-
Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacts, pars reticulata, and striatum.J Neurochem. 1989 Apr;52(4):1170-82. doi: 10.1111/j.1471-4159.1989.tb01863.x. J Neurochem. 1989. PMID: 2564423
-
Renal and intestinal autocrine monoaminergic systems: dopamine versus 5-hydroxytryptamine.Clin Exp Hypertens. 1997 Jan-Feb;19(1-2):43-58. doi: 10.3109/10641969709080803. Clin Exp Hypertens. 1997. PMID: 9028634 Review. No abstract available.
Cited by
-
[The role of cochlear neurotransmitters in tinnitus].HNO. 2007 Dec;55(12):964-71. doi: 10.1007/s00106-007-1624-7. HNO. 2007. PMID: 17943261 Review. German.
-
Effects of perinatal asphyxia on the mesostriatal/mesolimbic dopamine system of neonatal and 4-week-old male rats.Exp Brain Res. 1996 Dec;112(3):403-10. doi: 10.1007/BF00227946. Exp Brain Res. 1996. PMID: 9007542
-
Altered in vivo catecholamine release in the hypothalamic paraventricular nucleus of the aged rat.Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):161-7. doi: 10.1007/BF00168753. Naunyn Schmiedebergs Arch Pharmacol. 1996. PMID: 8717156
-
Pituitary physiological and ultrastructural changes during aging.Endocrine. 1995 Oct;3(10):711-6. doi: 10.1007/BF03000202. Endocrine. 1995. PMID: 21153159
-
[Pathogenesis and treatment of presbyacusis. Current status and future perspectives].HNO. 2008 Apr;56(4):429-32, 434-5. doi: 10.1007/s00106-008-1676-3. HNO. 2008. PMID: 18338147 Review. German.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
