Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2007 May 5;334(7600):911-2.
doi: 10.1136/bmj.39197.619190.80.

Onset of action of antidepressants

Andre Tylee, Paul Walters
Editorial

Onset of action of antidepressants

Andre Tylee et al. BMJ. .

Abstract

Most benefit is evident in the first two weeks, not six, as conventional wisdom says

PubMed Disclaimer

Conflict of interest statement

Competing interests: AT has received fees for speaking, consulting, and attending advisory boards of several companies that manufacture antidepressant drugs (Eli Lilly, Lundbeck, Wyeth, GSK, Servier, Pfizer, Organon, etc). He is currently receiving research funding from Servier Pharmaceuticals. PW has also received fees for speaking and attending advisory boards for several companies that manufacture antidepressants.

References

    1. National Collaborating Centre for Mental Health. Depression: management of depression in primary and secondary care Clinical guideline 23. 2004. London, National Institute for Health and Clinical Excellence. www.nice.org.uk/pdf/CG023NICEguideline.pdf
    1. Kuhn R. The treatment of depressive states with G22355 (imipramine hydrochloride). Am J Psychiatry 1958;115:459-64. - PubMed
    1. Pollack B. Clinical findings in the use of Tofranil in depressive and other psychiatric states. Am J Psychiatry 1959;116:317 - PubMed
    1. Vetulani J, Sundell K. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in the limbic forebrain. Nature 1975;257:495-6. - PubMed
    1. Banerjee SP, Kung LS. Development of B-adrenergic receptor subsensitivity by antidepressants. Nature 1977;268:455-6. - PubMed

Publication types

MeSH terms

Substances