Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1975 Dec;36(6 Suppl):2455-9.
doi: 10.1002/1097-0142(197512)36:6<2455::aid-cncr2820360630>3.0.co;2-w.

The chemistry of carcinoembryonic antigen

J E Coligan, W C Schnute Jr, M L Egan, C W Todd
Review

The chemistry of carcinoembryonic antigen

J E Coligan et al. Cancer. 1975 Dec.

Abstract

The structure of carcinoembryonic antigen is being determined as an approach to greater diagnostic specificity in the radioimmune assay. Examination by combined gas chromatography-mass spectrometry of derivatized saccharides from CEA has given a general outline of its carbohydrate structure. Sialic acid and fucose were completely destroyed, and galactose and mannose were partially destroyed by a single periodate treatment. Serial periodate oxidation (Smith degradation) destroyed additional amounts of galactose and mannose, as well as significant amounts of N-acetylglucosamine. Antigenic activity persisted, indicating that the residues destroyed played little, if any, part in the antigenicity of DEA.

PubMed Disclaimer

Publication types