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. 2007 Feb;13(2):282-6.
doi: 10.3201/eid1302.060539.

Neutralizing antibodies after infection with dengue 1 virus

Maria G Guzman  1 , Mayling Alvarez, Rosmari Rodriguez-Roche, Lidice Bernardo, Tibaire Montes, Susana Vazquez, Luis Morier, Angel Alvarez, Ernest A Gould, Gustavo Kouri, Scott B Halstead
Affiliations

Neutralizing antibodies after infection with dengue 1 virus

Maria G Guzman et al. Emerg Infect Dis. 2007 Feb.

Abstract

Severity of disease is markedly increased when infection with dengue virus type 2 (DENV-2) follows infection with DENV-1 at an interval of 20 years. Studies have shown that heterologous neutralizing antibody titers are inversely correlated with severity of a second infection. If this mechanism controlled disease severity in Cuba, heterotypic antibody titers should have declined over time. To determine whether phenotypic changes in dengue antibodies occur over time, we analyzed serum samples collected 4-8 and 20-22 years after DENV-1 infection. We found a significant increase in mean titer of homologous DENV-1 neutralizing antibodies and a significant decrease in heterologous antibodies to 1 of 2 genotypes of DENV-2 virus (the American genotype). Asian DENV-2 viruses were not neutralized during either interval; however, the American genotype underwent phenotypic changes in heterotypic viral neutralizing antibodies in the predicted direction. This finding may be related to the time-dependent changes in severity of disease found with secondary dengue infection.

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Figures

Figure
Figure
Log10 antibody (Ab) titers for human dengue virus type 1–immune serum samples collected in 1999 (89 samples) and 1981–1985 (50 samples, mean).
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