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Comment
. 2007 May 3;54(3):345-7.
doi: 10.1016/j.neuron.2007.04.025.

TRP channel knockout mice lose their cool

Man-Kyo Chung  1 , Michael J Caterina
Affiliations
Free article
Comment

TRP channel knockout mice lose their cool

Man-Kyo Chung et al. Neuron. .
Free article

Abstract

Heat and cold transduction by peripheral sensory neurons is a fundamental step in the avoidance of dangerous thermal extremes. In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures.

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Comment on

  • TRPM8 is required for cold sensation in mice.
    Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. Dhaka A, et al. Neuron. 2007 May 3;54(3):371-8. doi: 10.1016/j.neuron.2007.02.024. Neuron. 2007. PMID: 17481391
  • Attenuated cold sensitivity in TRPM8 null mice.
    Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N. Colburn RW, et al. Neuron. 2007 May 3;54(3):379-86. doi: 10.1016/j.neuron.2007.04.017. Neuron. 2007. PMID: 17481392

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