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Comment
. 2007 May 3;54(3):348-9.
doi: 10.1016/j.neuron.2007.04.014.

What is a schizophrenic mouse?

Nancy C Low  1 , John Hardy
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What is a schizophrenic mouse?

Nancy C Low et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Clapcote et al. examine mice containing missense mutations of the DISC1 gene, a locus associated with major mental illness in at least one large Scottish family. Genetic manipulation of mouse homologs of genes implicated in the etiology of psychiatric disorders is a promising avenue of research, but also one that is fraught with interpretative difficulties.

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  • Behavioral phenotypes of Disc1 missense mutations in mice.
    Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, Lerch JP, Trimble K, Uchiyama M, Sakuraba Y, Kaneda H, Shiroishi T, Houslay MD, Henkelman RM, Sled JG, Gondo Y, Porteous DJ, Roder JC. Clapcote SJ, et al. Neuron. 2007 May 3;54(3):387-402. doi: 10.1016/j.neuron.2007.04.015. Neuron. 2007. PMID: 17481393

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