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Review
. 2007 Jun-Aug;18(3-4):279-86.
doi: 10.1016/j.cytogfr.2007.04.005. Epub 2007 May 7.

TGF-beta1: a novel target for cardiovascular pharmacology

Santiago Redondo  1 , Carlos G Santos-Gallego, Teresa Tejerina
Affiliations
Review

TGF-beta1: a novel target for cardiovascular pharmacology

Santiago Redondo et al. Cytokine Growth Factor Rev. 2007 Jun-Aug.

Abstract

Transforming growth factor beta-1 (TGF-beta1) plays a key role in cardiovascular disease by a process which allows the loss of its protective properties. The first therapeutic attempt to restore its function by selectively designed novel drugs are being made. In addition, it has been recognized that the TGF-beta1 pathway is involved in the vascular mechanism of action of some current clinical drugs, such as acetylsalicylic acid, thiazolidinediones and statins. The aim of this paper is to review the possible value of TGF-beta1 as both a disease marker and a therapeutical target for cardiovascular disease.

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