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Review
. 2007 May 1:12:4402-8.
doi: 10.2741/2397.

DNA structure and human diseases

Sathees C Raghavan  1 , Michael R Lieber
Affiliations
Review

DNA structure and human diseases

Sathees C Raghavan et al. Front Biosci. .

Abstract

Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.

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