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. 2007 Jul;35(Web Server issue):W21-6.
doi: 10.1093/nar/gkm298. Epub 2007 May 7.

iHOP web services

José M Fernández  1 , Robert Hoffmann, Alfonso Valencia
Affiliations

iHOP web services

José M Fernández et al. Nucleic Acids Res. 2007 Jul.

Abstract

iHOP provides fast, accurate, comprehensive, and up-to-date summary information on more than 80,000 biological molecules by automatically extracting key sentences from millions of PubMed documents. Its intuitive user interface and navigation scheme have made iHOP extremely successful among biologists, counting more than 500,000 visits per month (iHOP access statistics: http://www.ihop-net.org/UniPub/iHOP/info/logs/). Here we describe a public programmatic API that enables the integration of main iHOP functionalities in bioinformatic programs and workflows.

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Figures

Figure 1.
Figure 1.
Schema of operations of iHOP web services. Each box is a web service, and double boxes are the recommended starting points for workflows. Links show some suggested flows between services that are useful for workflow building. Green links represent bi-directional flow, and black arrowed blue lines mean uni-directional flow. Grey thick lines illustrate bidirectional external access and orange dashed lines are accesses to the iHOP core (http://www.ihop-net.org/).
Figure 2.
Figure 2.
This is a Taverna workflow diagram which takes as input some free text (e.g. ‘breast cancer’). The workflow fetches the gene and protein symbols related to the input free text, and it returns those symbols, their synonyms and all the abstracts with sentences where the symbols are showing interaction evidences with other protein or gene symbols.
Figure 3.
Figure 3.
This is a snapshot of the CARGO framework, showing information about P53. The iHOP widget shows sentences with evidences of some relationship between P53 and other genes.
See this image and copyright information in PMC

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