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Review
. 2007;10(2):129-33.
doi: 10.1007/s11102-007-0035-9.

Normal levels of serum IGF-I: determinants and validity of current reference ranges

G Brabant  1 , H Wallaschofski
Affiliations
Review

Normal levels of serum IGF-I: determinants and validity of current reference ranges

G Brabant et al. Pituitary. 2007.

Abstract

Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I.

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