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. 2007 Mar-Apr;11(2):369-71.
doi: 10.1111/j.1582-4934.2007.00029.x.

The effect of Cyclosporine A on cardiomyocytes differentiation

Liliana Paslaru  1 , Sean Davidson, Irinel Popescu, Michel Morange
Affiliations

The effect of Cyclosporine A on cardiomyocytes differentiation

Liliana Paslaru et al. J Cell Mol Med. 2007 Mar-Apr.

Abstract

Cyclosporine A (CsA) is a powerful immunosuppressive drug which significantly improved the success of organ transplantation; however, the major limiting factors for the drug's clinical use are its long and short term adverse effects. The present study was conducted to examine, in a dose-dependent manner, in a model of cardiogenesis, the effect of CsA on cardiomyocytes differentiation.

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Figures

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A, B. Cell aggregates. A. Control (DMSO 1%). B. Cyclosporin A (CsA) 10μM. C–H. Patterns of HSP25 and myocardial actin during differentiation of cardiomyocytes (from carcinoembryonar C19 cell line). Red Cy3 (HSP25), green FITC (actin), blue Hoechst. C. Control, DMSO 1% (10x); D. DMSO 1%, CsA 1.25μM (10x); E. DMSO 1%, CsA 5μM(10x); F. DMSO 1%, CsA 10μM (10x); G. CsA 5μM (40x); H. CsA 10μM (10x)
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References

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