Comment
doi: 10.1016/j.devcel.2007.04.010.
Cytokinetic pyrotechnics
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- PMID: 17488616
- DOI: 10.1016/j.devcel.2007.04.010
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Comment
Cytokinetic pyrotechnics
Dev Cell.
2007 May.
Free article
Abstract
Cytokinesis, the final step in cell division, is dependent on formation and closure of a ring of actin filaments (F-actin) and myosin-2 which is, in turn, dependent on activation of the small GTPase, RhoA, at the cell equator. Four new papers, including two in this issue of Developmental Cell (Petronczki et al., 2007; Birkenfeld et al., 2007), provide new insights into how RhoA activation at the equator is initiated and maintained.
Comment on
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GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.Dev Cell. 2007 May;12(5):699-712. doi: 10.1016/j.devcel.2007.03.014. Dev Cell. 2007. PMID: 17488622 Free PMC article.
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Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.Dev Cell. 2007 May;12(5):713-25. doi: 10.1016/j.devcel.2007.03.013. Dev Cell. 2007. PMID: 17488623
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