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Comment
. 2007 May 15;104(20):8205-6.
doi: 10.1073/pnas.0703091104. Epub 2007 May 8.

Subtype-selective sodium channel blockers promise a new era of pain research

Birgit T Priest  1 , Gregory J Kaczorowski
Affiliations
Comment

Subtype-selective sodium channel blockers promise a new era of pain research

Birgit T Priest et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: B.T.P. and G.J.K. are employees of Merck & Co., Inc., and own stock and hold stock options in the company.

Figures

Fig. 1.
Fig. 1.
Effects of tetrodotoxin (TTX) and A-803467 on sodium current in an injured rat. Red traces indicate the current in the presence of the blocker.
See this image and copyright information in PMC

Comment on

  • A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Jarvis MF, Honore P, Shieh CC, Chapman M, Joshi S, Zhang XF, Kort M, Carroll W, Marron B, Atkinson R, Thomas J, Liu D, Krambis M, Liu Y, McGaraughty S, Chu K, Roeloffs R, Zhong C, Mikusa JP, Hernandez G, Gauvin D, Wade C, Zhu C, Pai M, Scanio M, Shi L, Drizin I, Gregg R, Matulenko M, Hakeem A, Gross M, Johnson M, Marsh K, Wagoner PK, Sullivan JP, Faltynek CR, Krafte DS. Jarvis MF, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. doi: 10.1073/pnas.0611364104. Epub 2007 May 2. Proc Natl Acad Sci U S A. 2007. PMID: 17483457 Free PMC article.

References

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