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. 2007 Jun 7;9(12):2361-4.
doi: 10.1021/ol0707362. Epub 2007 May 10.

A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans

Jossian Oppenheimer  1 , Whitney L Johnson, Michael R Tracey, Richard P Hsung, Pei-Yuan Yao, Renhe Liu, Kang Zhao
Affiliations

A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans

Jossian Oppenheimer et al. Org Lett. .

Abstract

A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.

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