doi: 10.1016/j.bmcl.2006.12.068.
Epub 2006 Dec 23.
One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst
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- PMID: 17490874
- DOI: 10.1016/j.bmcl.2006.12.068
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One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst
Bioorg Med Chem Lett.
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Abstract
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.
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