Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 May;55(5):769-74.
doi: 10.1111/j.1532-5415.2007.01140.x.

Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women

Matthew J Delmonico  1 , Tamara B Harris, Jung-Sun Lee, Marjolein Visser, Michael Nevitt, Stephen B Kritchevsky, Frances A Tylavsky, Anne B Newman; Health, Aging and Body Composition Study
Affiliations

Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women

Matthew J Delmonico et al. J Am Geriatr Soc. 2007 May.

Abstract

Objectives: To compare two methods for classifying an individual as sarcopenic for predicting decline in physical function in the Health, Aging and Body Composition Study.

Design: Observational cohort study with 5 years of follow-up.

Setting: Communities in Memphis, Tennessee, and Pittsburgh, Pennsylvania.

Participants: Men and women aged 70 to 79 (N=2,976, 52% women, 41% black).

Measurements: Appendicular lean mass (aLM) was measured using dual energy x-ray absorptiometry, and participants were classified as sarcopenic first using aLM divided by height squared and then using aLM adjusted for height and body fat mass (residuals). Incidence of persistent lower extremity limitation (PLL) was measured according to self-report, and change in objective lower extremity performance (LEP) measures were observed using the Short Physical Performance Battery.

Results: There was a greater risk of incident PLL in women who were sarcopenic using the residuals sarcopenia method than in women who were not sarcopenic (hazard ratio (HR)=1.34, 95% confidence interval (CI)=1.11-1.61) but not in men. Those defined as sarcopenic using the aLM/ht(2) method had lower incident PLL than nonsarcopenic men (HR=0.76, 95% CI=0.60-0.96) and women (HR=0.75, 95% CI=0.60-0.93), but these were no longer significant with adjustment for body fat mass. Using the residuals method, there were significantly poorer LEP scores in sarcopenic men and women at baseline and Year 6 and greater 5-year decline, whereas sarcopenic men defined using the aLM/ht(2) method had lower 5-year decline. Additional adjustment for fat mass attenuated this protective effect.

Conclusion: These findings suggest that sarcopenia defined using the residuals method, a method that considers height and fat mass together, is better for predicting disability in an individual than the aLM/ht(2) method, because it considers fat as part of the definition.

PubMed Disclaimer

Publication types