Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Dec;60(12):1328-32.
doi: 10.1136/jcp.2006.041731. Epub 2007 May 11.

Demystifying basal-like breast carcinomas

L Da Silva  1 , C Clarke, S R Lakhani
Affiliations
Review

Demystifying basal-like breast carcinomas

L Da Silva et al. J Clin Pathol. 2007 Dec.

Abstract

"Basal" breast cancers are dominating the breast research literature at present and pathologists are under increasing pressure to evaluate for such a phenotype by their surgical and oncological colleagues. There is also much confusion about how to assess cancers, which immunohistochemical markers to use, what meaning and benefit this provides, and what the surgeons and oncologists will do with the information. Much remains to be done to answer all these questions but here we try to shed light on some of the issues and suggest what is still to come.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Perou C M, Sorlie T, Eisen M B.et al Molecular portraits of human breast tumours. Nature 2000406747–752. - PubMed
    1. Sorlie T, Perou C M, Tibshirani R.et al Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 20019810869–10874. - PMC - PubMed
    1. Pawlina M H R W. Female reproductive system. Histology. A text and atlas , 5th edn. Philadelphia, PA: Lippincott Williams & Wilkins 2006804–806.
    1. Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol 197053161–220. - PubMed
    1. Moll R, Franke W W, Schiller D L.et al The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 19823111–24. - PubMed

Publication types