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. 2007 Jun;39(6):724-6.
doi: 10.1038/ng2048. Epub 2007 May 13.

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina  1 , David Meyre, Sophie Gallina, Emmanuelle Durand, Antje Körner, Peter Jacobson, Lena M S Carlsson, Wieland Kiess, Vincent Vatin, Cecile Lecoeur, Jérome Delplanque, Emmanuel Vaillant, François Pattou, Juan Ruiz, Jacques Weill, Claire Levy-Marchal, Fritz Horber, Natascha Potoczna, Serge Hercberg, Catherine Le Stunff, Pierre Bougnères, Peter Kovacs, Michel Marre, Beverley Balkau, Stéphane Cauchi, Jean-Claude Chèvre, Philippe Froguel
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Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina et al. Nat Genet. 2007 Jun.

Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

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