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. 1991 Dec 13;254(5038):1654-6.
doi: 10.1126/science.1749937.

Intracellular signaling by 14-hydroxy-4,14-retro-retinol

J Buck  1 , F Derguini, E Levi, K Nakanishi, U Hämmerling
Affiliations

Intracellular signaling by 14-hydroxy-4,14-retro-retinol

J Buck et al. Science. .

Abstract

In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.

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