doi: 10.1128/iai.13.1.298-301.1976.
Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B
- PMID: 175019
- PMCID: PMC420610
- DOI: 10.1128/iai.13.1.298-301.1976
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Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B
Infect Immun.
1976 Jan.
Abstract
Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.
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