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. 1976 Jan;13(1):298-301.
doi: 10.1128/iai.13.1.298-301.1976.

Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B

D C Morrison, D M Jacobs

Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B

D C Morrison et al. Infect Immun. 1976 Jan.

Abstract

Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.

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References

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