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Review
. 2007 May;9(2):101-8.
doi: 10.1007/s11926-007-0003-4.

Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus

Deborah M Friedman  1 , Ann Rupel, Jill P Buyon
Affiliations
Review

Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus

Deborah M Friedman et al. Curr Rheumatol Rep. 2007 May.

Abstract

Neonatal lupus syndrome is a model of passively acquired autoimmunity in which the pregnant woman's serum contains specific antibodies to 52 or 60 kd SSA/Ro and/or 48 kd SSB/La, which cross the placenta and are associated with the development of congenital heart block in the fetus and/or a transient rash or various liver and blood cell abnormalities in the newborn. To date, congenital heart block is a permanent condition that entails significant morbidity and mortality, with nearly all affected infants requiring pacemakers and with an 80% cumulative probability of survival at 3 years of age. An intensive search is on for the specific etiopathophysiology and for new clinical tools to approach and treat this disease.

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References

    1. Ultrasound Obstet Gynecol. 2004 Sep;24(4):467-72 - PubMed
    1. Obstet Gynecol. 1999 Jun;93(6):952-7 - PubMed
    1. Am J Perinatol. 2002 Feb;19(2):73-80 - PubMed
    1. Eur J Immunol. 2001 Feb;31(2):573-9 - PubMed
    1. Arthritis Rheum. 2003 Jan;48(1):280-1; author reply 281-2 - PubMed

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