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Randomized Controlled Trial
. 2007 Jul;51(7):2628-30.
doi: 10.1128/AAC.00206-07. Epub 2007 May 14.

Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus

Mary Jo Cenizal  1 , Daniel Skiest, Samuel Luber, Roger Bedimo, Pat Davis, Patrick Fox, Kathleen Delaney, R Doug Hardy
Affiliations
Randomized Controlled Trial

Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus

Mary Jo Cenizal et al. Antimicrob Agents Chemother. 2007 Jul.

Abstract

To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

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