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Comparative Study
. 2007:2007:35457.
doi: 10.1155/2007/35457. Epub 2007 Mar 21.

Anxiety in mice: a principal component analysis study

Yan Clément  1 , Chantal Joubert, Caroline Kopp, Eve M Lepicard, Patrice Venault, René Misslin, Martine Cadot, Georges Chapouthier
Affiliations
Comparative Study

Anxiety in mice: a principal component analysis study

Yan Clément et al. Neural Plast. 2007.

Abstract

Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.

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Figures

Figure 1
Figure 1
Mean scores by strain and gender of component values, S = strain effect; G = gender effect; SXG = strain-gender interaction, ** = P < .01; **** = P < .0001.
Figure 2
Figure 2
Mean scores by strain and gender of component values, S = strain effect; G = gender effect; SXG = strain-gender interaction, * = P < .04; ** = P < .01; **** = P < .0001.
See this image and copyright information in PMC

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