Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007:2007:78171.
doi: 10.1155/2007/78171. Epub 2007 Jan 10.

Neurobiology of memory and anxiety: from genes to behavior

Allan V Kalueff  1
Affiliations
Review

Neurobiology of memory and anxiety: from genes to behavior

Allan V Kalueff. Neural Plast. 2007.

Abstract

Interaction of anxiety and memory represents an essential feature of CNS functioning. This paper reviews experimental data coming from neurogenetics, neurochemistry, and behavioral pharmacology (as well as parallel clinical findings) reflecting different mechanisms of memory-anxiety interplay, including brain neurochemistry, circuitry, pharmacology, neuroplasticity, genes, and gene-environment interactions. It emphasizes the complexity and nonlinearity of such interplay, illustrated by a survey of anxiety and learning/memory phenotypes in various genetically modified mouse models that exhibit either synergistic or reciprocal effects of the mutation on anxiety levels and memory performance. The paper also assesses the putative role of different neurotransmitter systems and neuropeptides in the regulation of memory processes and anxiety, and discusses the role of neural plasticity in these mechanisms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Stress, memory, and anxiety interplay.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Clement Y, Chapouthier G. Biological bases of anxiety. Neuroscience and Biobehavioral Reviews. 1998;22(5):623–633. - PubMed
    1. Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. Journal of Clinical Psychiatry. 2001;62(supplement 11):22–27. - PubMed
    1. Nutt DJ. Overview of diagnosis and drug treatments of anxiety disorders. CNS Spectrums. 2005;10(1):49–56. - PubMed
    1. Nutt DJ, Malizia AL. New insights into the role of the GABAA-benzodiazepine receptor in psychiatric disorder. British Journal of Psychiatry. 2001;179:390–396. - PubMed
    1. Nutt DJ, Ballenger JC, Sheehan D, Wittchen H-U. Generalized anxiety disorder: comorbidity, comparative biology and treatment. International Journal of Neuropsychopharmacology. 2002;5(4):315–325. - PubMed

Publication types