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. 2007 Jun 4;96(11):1767-71.
doi: 10.1038/sj.bjc.6603798. Epub 2007 May 15.

Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003

M van Blankenstein  1 , C W N Looman, P D Siersema, E J Kuipers, J W W Coebergh
Affiliations

Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003

M van Blankenstein et al. Br J Cancer. .

Abstract

Over the 15-year period 1989-2003, the incidence of oesophagus-cardia adenocarcinoma in the Netherlands rose annually by 2.6% for males and 1.2% for females. This was the net outcome of annual increases in the incidence of adenocarcinoma of the oesophagus (ACO) of 7.2% for males and 3.5% for females and annual declines in the incidence of adenocarcinoma of the gastric cardia (AGC) of more than 1% for both genders. Nonlinear cohort patterns were found in females with ACO and for both genders in AGC; a nonlinear period pattern was observed only in males with AGC. These differing epidemiological patterns for ACO and AGC do not support a common aetiology. Proposed underlying factors for the rise in ACO incidence appear to have little effect on AGC incidence. This and the secular decline in smoking among males may have led to the decline in AGC incidence.

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Figures

Figure 1
Figure 1
The annual European standardised rates for ACO and AGC by gender for the period 1989–2003.
Figure 2
Figure 2
The age–period models for both ACO and AGC in males.
Figure 3
Figure 3
The age-cohort model diagram for AGC in males and females.
See this image and copyright information in PMC

References

    1. Bardou M, Barkun AN, Ghosn J, Hudson M, Rahme E (2004) Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence. Clin Gastroenterol Hepatol 2: 880–887 - PubMed
    1. Barendregt JJ, Looman CW, Bronnum-Hansen H (2002) Comparison of cohort smoking intensities in Denmark and the Netherlands. Bull World Health Organ 80: 26–32 - PMC - PubMed
    1. Bollschweiler E, Wolfgarten E, Gutschow C, Holscher AH (2001) Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer 92: 549–555 - PubMed
    1. Buttar NS, Wang KK, Leontovich O, Westcott JY, Pacifico RJ, Anderson MA, Krishnadath KK, Lutzke LS, Burgart LJ (2002) Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. Gastroenterology 122: 1101–1112 - PubMed
    1. Bytzer P, Christensen PB, Damkier P, Vinding K, Seersholm N (1999) Adenocarcinoma of the esophagus and Barrett's esophagus: a population- based study. Am J Gastroenterol 94: 86–91 - PubMed