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. 2007 Jul;45(7):2316-20.
doi: 10.1128/JCM.00203-07. Epub 2007 May 16.

PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome

Peggy C R Godschalk  1 , Alex van Belkum, Nicole van den Braak, Diana van Netten, C Wim Ang, Bart C Jacobs, Michel Gilbert, Hubert P Endtz
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PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome

Peggy C R Godschalk et al. J Clin Microbiol. 2007 Jul.

Abstract

Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.

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References

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