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. 1991;86(1):1-9.
doi: 10.1007/BF01250371.

A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

S C Gilman  1 , J S Colton, Y Grossman
Affiliations

A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

S C Gilman et al. J Neural Transm Gen Sect. 1991.

Abstract

Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on 45Ca2+ uptake and [3H]GABA release using a calcium ionophore A 23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated 45Ca2+ uptake. On the other hand, both depolarization-induced 45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.

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