Review
doi: 10.1016/j.cell.2007.05.004.
DegrAAAded into silence
Affiliations
- PMID: 17512398
- DOI: 10.1016/j.cell.2007.05.004
Item in Clipboard
Review
DegrAAAded into silence
Cell.
.
Free article
Abstract
In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Bühler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.
Comment on
-
Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing.Cell. 2006 Jun 2;125(5):873-86. doi: 10.1016/j.cell.2006.04.025. Cell. 2006. PMID: 16751098
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
