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Review
. 2007 Apr;21(2):293-302.
doi: 10.1016/j.hoc.2007.03.010.

HER2-positive advanced breast cancer

Nicholas J Robert  1 , Anne M Favret
Affiliations
Review

HER2-positive advanced breast cancer

Nicholas J Robert et al. Hematol Oncol Clin North Am. 2007 Apr.

Abstract

It is important when treating a patient who has advanced breast cancer to establish the biologic characteristics of the tumor. In addition to knowing the hormone receptor status (estrogen and progesterone), human epidermal receptor 2 (HER2) should be evaluated. The measurement of this parameter is essential to optimizing the systemic management. This article reviews the biology of HER2, testing for HER2, clinical studies evaluating HER2-based therapies, side effects (specifically cardiotoxicity), and strategies for HER2-based therapies.

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