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. 2007 Jun 13;129(23):7274-6.
doi: 10.1021/ja071905g. Epub 2007 May 22.

syn-1,2-Amino alcohols via diastereoselective allylic C-H amination

Kenneth J Fraunhoffer  1 , M Christina White
Affiliations

syn-1,2-Amino alcohols via diastereoselective allylic C-H amination

Kenneth J Fraunhoffer et al. J Am Chem Soc. .
No abstract available

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Figures

Scheme 1<sup>a</sup>
Scheme 1a
a Conditions: (a) RuCl3 (5 mol %), NaIO4 (5 equiv), CH3CN/CCl4/H2O (2:2:3), room temp (82%); (b) sodium naphthalene (8 equiv), DME, −78 °C; (c) 6 M HCl, 100 °C (63%, two steps).
Scheme 2<sup>a</sup>
Scheme 2a
a Conditions: (a) 1 (10 mol %), 5 mol % additional bis-sulfoxide, PhBQ (1.05 equiv), THF (0.66 M), 45 °C, 72 h; (b) BCl3 (5 equiv), CH2Cl2, room temp, 72%.
Scheme 3
Scheme 3
Scheme 4
Scheme 4
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References

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